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This section lists medications that have been used to treat navicular disease, all of these should be used only with the recommendation and guidance from your veterinarian.

Phenylbutazone (Bute) is an NSAID (Nonsteroidal anti-inflammatory drug) which is often used to temporarily relieve pain while giving time for other treatments to work.  Bute should not be used long term as it can lead to ulcers and other digestive problems.

Isoxsuprine is a drug that dilates blood vessels allowing more circulation to the foot.  It has been effective for some horses, although other treatments are more often used these days.  Isoxsuprine does have side effects so should be used with caution.  Personal Note: When my horse first came up lame we tried this drug for about a month and saw no improvement.

Tilduronate (Tildren) is an osteoporosis drug that has been used mostly in Europe to stop the degeneration of the navicular bone.  There has been some success with this drug especially with horses in early stages of navicular disease. This drug must be administered by a veterinarian intravenously and can be quite expensive.  There are reports on horse forums suggesting that this treatment may be linked to fractures, there are similar reports of fractures in women who have been on other osteoporosis drugs.  This link is not certain but is has been suggested that these drugs inhibit normal breakdown and remodeling of bone that happens as a result of stress, therefore the bone may be gradually weakened.

Corticosteroids can be injected directly into the navicular bursa to relieve inflammation for several months.  This procedure is discussed on its own page.  Personal Note:  I have used this procedure with success on my horse, Bo.

Adequan or hyaluronic acid can also be injected into the joint, this is generally used for arthritic conditions.  A 2009 study by Bell, et al found little benefit from injecting this drug in the navicular bursa, though injection of corticosteroids did have a positive effect.



Some supplements can be helpful in alleviating pain associated with navicular syndrome, these are discussed on their own Supplements page.  Also TLC, the makers of EquiBone claim that their product can help to improve the bone mineralization process and stop or slow the degeneration of the navicular bone.

Equi-bone:  The makers of Equi-bone claim that this supplement provides minerals and vitamins that improve circulation and facilitate optimal blood chemistry to support healthy bone remodeling and reduce mineral loss from bone.  The manufacturers recommend a loading period of 5-7 months, during which you feed double the maintenance amount.  You can go to the maintenance dosage sooner than that if you see significant improvement.  Below is the list of ingredients from the TLC website for the pellet version.  The powder form is the same with the exception that it does not have MSM or Glucosamine.  Equi-bone is more expensive than your usual supplement, but if it works as the makers claim it will be worth the price.

Equi-Bone Pellet Ingredients: Dicalcium Phosphate, Calcium Proteinate, Magnesium Proteinate, Potassium Chloride, Potassium Amino Acid Complex, Yeast Culture, Glucosamine Hcl, Methyl Sulfonyl Methane, Salt, Dehydrated Forage Products, Iron Proteinate, Vitamin B-12, Copper Proteinate, Choline Chloride, Zinc Proteinate, Niacin, Potassium Sulphate, Calcium Pantothenate, Cane Molasses, Inositol, Linseed Meal, l-Lysine, dl-Methionine, l-Aspartic Acid, l-Arginine, Dried Aspergillus Oryzae Fermentation Extract, Wheat Bran, Wheat Middlings, Tocopherol (Source of Vitamin E), Biotin, Sodium Selenite, p-Aminobenzoic Acid, Ascorbic Acid, Vitamin K, Cobalt Proteinate, Flavoring, Ethylenediamine Dihydriodide, Pyridixoine HCl, Folic Acid, Thiamin, Manganese Proteinate, Vitamin A, Riboflavin, Soybean Oil
*Equi-Bone Powder does not have Glucosamine or MSM added.

Updated September 1, 2014


  1. Lee Bradley says:

    Will you be covering procedures?

    • Janice says:

      Yes. Keep checking back, I have a lot more information to share. Next I will be adding an article on steroid injections that were successful with Bo.

  2. eileen sammons says:

    I recently purchased a 17 year old gelding with soundness issues. His 2nd owner was told by the first that he has navicular. He has some old hoof damage on right front, and has been wearing bar shoe on it. My first step to getting him sound was to call in my natural barefoot farrier. I felt sure the ‘corrective’ shoe was a big part of his limping. My farrier pulled the shoe, started a natural trim to correct the balance of the hoof which had heels too long, little contact with the ground in the frog. Our regimen on trimming will be a slight correction every 6 weeks. In addition I am soaking the foot in apple cider vinegar for 20 minutes daily, per farrier instruction. The way this horse walked improved immediately upon removal of the heavy ring shoe. Another part of his treatment is Equi-Bone, which I ordered and started him on immediately. We are in week one of trying to get this horse sound again. I have more hope for him now than I did prior to my farrier coming out.

  3. Becky says:

    Could you please email me a regiment that you are using on Bo. What supplements? What about the steroid injections? I have a 10 year old mare that has what they call “swiss cheese” in her navicular bones. So any advice or direction would be appreciated.

  4. Kim R says:

    Can you tell me more about your experience with Duralactin. I have had me gelding on Eqi-Bone and it does not seem to be working as well as it use to. I want to try some other supplement before i move to injections.

    • Janice says:

      Duralactin did seem to alleviate Bo’s pain when he was on it. It did seem to extend by a month at least the time between injections. Unfortunately I didn’t get to test it for as long as I wanted to because he tore his tendon and I had to shift treatment to that.

      The injections did help Bo for about 5-6 months at a time. Please see my reply to another reader about injections:

      Thanks for visiting Navicular Horse and good luck with your horse’s treatment.

      If you find that Duralactin helps please come back and let us know.

  5. Lynn Van Gilder says:

    My horse didn’t show clinical signs of being lame on both feet and one vet who xrayed him did flexions and lounged both ways only showed lameness on right front. An MRI showed sesamoid ligament injury and collateral medial injury. He is 11 years old and this was a sudden onset. I cannot afford treatments if onsurance company doesn’t cover and the only way I could afford to keep him was by leasing him which has stopped. Is there anything I can do short of putting him down?

    • Janice says:

      Sorry to hear about your horse. I’m not a vet so I can’t give veterinary advice. A lot of the treatments I discuss on the blog cost at a minimum $300 per treatment, so there is nothing that is cheap. I might suggest trying Easy Willow or Duralactin for pain relief, but neither one will solve the problem completely. The only other suggestion I have is that some people start Go Fund Me pages to help pay for things like this. If you have a lot of friends and post it on Facebook you could get some financial help that way. Hopefully the insurance will cover the treatment. Sorry I couldn’t help more, I encourage anyone else who has a suggestion to post it here. Good luck!

  6. John says:

    We had great results from equi-bone after just one loading dose. The company claims 60+% positive results.

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